Novel antimicrobial strategy: native postbiotics synergize with antibiotics to overcome resistance in Klebsiella pneumoniae.

ABSTRACT:

Background

The alarming rise of antimicrobial resistance (AMR), especially in Klebsiella pneumoniae, demands urgent development of novel therapeutic strategies. Recently, probiotics and their metabolites, known as postbiotics, have gained attention due to their potential to enhance antibiotic efficacy and combat resistant pathogens.

Methods

In this study, 88 native Lactobacillus spp. isolates, were screened for antimicrobial activity against a highly resistant K. pneumoniae ATCC 7881 strain with a minimum inhibitory concentration ≥ 2048 µg/mL. Based on screening results, four strains-Lactiplantibacillus plantarum RP155, 403, 225 and Ligilactobacillus salivarius RP317-were selected to produce postbiotics. Antimicrobial activity of these postbiotics, alone and combined with su

SUBMITTER: Aghamohammad S 

PROVIDER: S-EPMC12604375 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature