Female Anterior Cruciate Ligaments Exhibit a Muted Mechanobiological Response to Mechanical Loading.

ABSTRACT: Female athletes are significantly more likely to tear their anterior cruciate ligament (ACL) compared to their male counterparts. While there are several potential reasons for this, previous data from our lab demonstrated that female ACL explants have an impaired remodeling response to loading, which may prevent the repair of fatigue damage and lead to increased ACL rupture. The objective of this study was to identify the biological mechanisms driving the impaired remodeling of female ACLs to cyclic loading, including the role of estrogen. ACLs were harvested from male and female New Zealand white rabbits and cyclically loaded in a tensile bioreactor, followed by bulk RNA-sequencing. Additional ACL explants treated with or without estradiol were analyzed using RT-qPCR to determine the regu

SUBMITTER: Paschall L 

PROVIDER: S-EPMC12604462 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature