Alterations in nutrient availability in the lungs during <i>Streptococcus pneumoniae</i>-induced pneumonia.

ABSTRACT: Streptococcus pneumoniae is a leading cause of pneumonia. Importantly, the extent and impact of changes in the infected airway on bacterial nutrient availability and gene expression are not known. Utilizing untargeted UPLC-ESI-MS/MS metabolomics, we comprehensively characterized the metabolic landscape in the airway across early, mid, and severe stages of pneumococcal pneumonia. This revealed that dynamic shifts in metabolites occurred during pneumonia, with an initial influx of metabolites at the early stage, followed by declines as the disease progressed. Specific host metabolic perturbations were indicative of purine dysregulation, cellular stress, and outright tissue injury. Levels of glucose, a known modulator of pneumococcal capsule production, were highest at the early diseas

SUBMITTER: Im H 

PROVIDER: S-EPMC12604485 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature