Protein tyrosine phosphatase PTP1B is a positive regulator of the intracellular development of <i>Chlamydia trachomatis</i>.

ABSTRACT: The intracellular survival and replication of Chlamydia trachomatis rely on the precise manipulation of host signaling pathways. Host kinases are instrumental in the modulation of host signaling during C. trachomatis infection. However, the potential contribution of host phosphatases to chlamydial pathogenesis remains poorly understood. Here, we identified the host tyrosine phosphatase PTP1B as a positive regulator of C. trachomatis intracellular development. Gain-of-function approaches revealed that PTP1B promotes inclusion development and increases the production of infectious elementary bodies, whereas loss-of-function by chemical inhibition or silencing leads to a reduction in both inclusion size and bacterial infectivity. Interestingly, PTP1B inhibition did not af

SUBMITTER: Khan MS 

PROVIDER: S-EPMC12604487 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature