Development and optimization of green extraction of naringin in <i>Citrus grandis</i> 'Tomentosa' using natural deep eutectic solvents (NADES) and investigation of lung cancer therapeutics mechanisms.

ABSTRACT: Natural bioactive compounds derived from traditional Chinese medicine have garnered widespread research interest. In this study, a green and efficient method for extracting naringin from Citrus grandis 'Tomentosa' (CGT) was developed using ultrasonic-assisted extraction (UAE) with the natural deep eutectic solvent (NADES) composed of choline chloride and levulinic acid (ChCl-Le). The extraction was carried out under the conditions of 40% (w/w) water content in NADES, a solid-to-liquid ratio of 1 : 65 (w/v), a temperature of 60 °C, an extraction time of 40 minutes, and an ultrasonic power of 300 W. Despite optimized and practical conditions, a high naringin yield of 4.7% was attained. This yield remains significantly greater than those obtained with methanol (4.1%) or ethanol (4.0%).

SUBMITTER: Yang J 

PROVIDER: S-EPMC12604616 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature