Loeffler endocarditis in hypereosinophilic syndrome, the paradox of absent peripheral eosinophilia: a case report.

ABSTRACT:

Background

Loeffler endocarditis is a cardiac disease characterized by infiltration of eosinophils in hypereosinophilic syndrome (HES), progressing through acute necrotic, thrombotic, and fibrotic stages. It can ultimately lead to heart failure and restrictive cardiomyopathy. Early recognition, multidisciplinary approach, and accurate treatment are crucial to prevent these complications.

Case summary

A 51-year-old man presented with dyspnoea and chest discomfort. Imaging revealed a large left ventricular (LV) thrombus, a reduced LV ejection fraction (LVEF 28%), and a typical 'double-V pattern' of endomyocardial fibrosis. Despite characteristic imaging findings of Loeffler endocarditis, the absence of peripheral eosinophilia reduced clinical suspicion. Coronary disease was ex

SUBMITTER: Heymans ABM 

PROVIDER: S-EPMC12604622 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature