Gene dependence during mammalian <i>Acinetobacter baumannii</i> pneumonia and septicaemia infections.

ABSTRACT: With a limited number of traditional virulence factors, the success of the nosocomial pathogen Acinetobacter baumannii is largely attributed to its ability to persist and resist. The niches encountered during infection vary significantly from the more commonly studied laboratory setting, and consequently, the genes responsible for in vivo pathogenesis have yet to be fully elucidated. This study utilized the A. baumannii AB5075-UW transposon mutant library with unbiased genome-wide transposon sequencing to identify the genetic basis for survival and fitness during pneumonia and septicaemia infections. We identified 128 genes essential for in-host survival, including 22 required for survival in all tissues. Additionally, 302 genes with significantly altered fitness in

SUBMITTER: Morris FC 

PROVIDER: S-EPMC12604733 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature