Effects of Heat Exposure on Kynurenine Pathway Metabolism-Comparison Between Exertional and Exogenous Heating of the Human Body.

ABSTRACT:

Background

The kynurenine pathway (KP) plays a pivotal role in many diseases that involve distinct pathological mechanisms.

Objectives

Since KP metabolites are potential disease biomarkers, it is crucial to investigate their fluctuations under physiological conditions. As the KP is stress-responsive, this study examines how peripheral KP metabolites change with core temperature increases induced by two different modalities.

Methods

In this randomized cross-over study, 11 young healthy males were subjected to (a) exogenous heating via hot water immersion (44°C, EXO), and (b) exertional heating via exercise (EXE), until rectal temperature (T_rec) reached 39°C, followed by a recovery phase. Blood samples were collected at baseline and at every 0.5°C T_rec</

SUBMITTER: Louvrou V 

PROVIDER: S-EPMC12604745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature