Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model.

ABSTRACT: The seven mammalian isoforms of 14-3-3 are each encoded by a unique gene and function as phosphorylation dependent protein modulators. Because 14-3-3 proteins have particularly high expression in the brain, they have been implicated in a variety of neuronal functions. Recently, we showed that functional knockout of all 14-3-3 isoforms in forebrain glutamatergic neurons of mice is sufficient to induce schizophrenia-like endophenotypes. Human and animal studies have linked mutations in Ywhae and 14-3-3ε expression changes to certain neurodevelopmental and psychiatric diseases. In this study, we conditionally knocked out 14-3-3ε from forebrain glutamatergic neurons by crossing Ywhaeflox/flox mice with CaMKIIα-Cre mice. Ywhaeflox/flox Cre+ (conditional knockout -CKO) mice and their Ywhaeflox/f

SUBMITTER: Navarrete-Mathews M 

PROVIDER: S-EPMC12604760 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature