The relationship between serum eosinophil peroxidase and major basic protein levels in relation to severity and response to H1 antihistamines in chronic spontaneous Urticaria.

ABSTRACT:

Objective

In chronic spontaneous urticaria (CSU), the significance of serum Eosinophil Peroxidase (EPO) and Major Basic Protein (MBP) levels as indicators of disease severity and response to antihistamine treatment is currently inadequately understood. This study explores the correlation between serum EPO and MBP levels, the severity of the disease, and the efficacy of antihistamines in patients with CSU.

Methods

A cross-sectional study involved 120 CSU patients alongside 30 healthy controls. In addition, a cohort study targeted 60 patients diagnosed with severe CSU, defined by a Urticaria Activity Score over 7 days (UAS7 ≥ 28). Initially, these patients received a dose of 20 mg of bilastine, which could be increased to a maximum of 80 mg depending on the results of the Urti

SUBMITTER: Nguyen CTK 

PROVIDER: S-EPMC12604763 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature