Risk factors for Buruli ulcer disease in Ghana: A matched case-control study in four selected endemic districts of Eastern and Oti Regions.

ABSTRACT:

Background

Buruli ulcer disease (BUD) remains a poorly understood neglected tropical disease (NTD). The 2021-2030 WHO NTD Roadmap prioritises addressing knowledge gaps in BUD transmission and calls for the need to better understand the factors contributing to disease occurrence. In Ghana, reported BUD cases declined from over 600 in 2018 to 81 in 2023. While previous case-control studies in Ghana have used a 1:1 matching ratio, this study examined potential risk factors for BUD in four endemic districts using an improved methodological approach.

Methods

A community-based 1:2 matched case-control study was conducted in four BUD-endemic districts (Akwapim South, Akwapim North-Okere, Jasikan, and Biakoye) in the Eastern and Oti Regions of Ghana. Seventy (70) BUD cases and 140 c

SUBMITTER: Gohoho M 

PROVIDER: S-EPMC12604775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature