Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels.

ABSTRACT: Fast skeletal muscle fibers from zebrafish share a number of functional properties with mammalian twitch muscle fibers, making this vertebrate a precious model to investigate the pathophysiology of neuromuscular disorders. We previously reported that action potentials (APs) from zebrafish fast fibers exhibit low amplitude and require unusually strong negative resting membrane voltage levels to be elicited. In this study, using voltage-clamp and current-clamp techniques, we explored the properties of voltage-gated Na+ channels (NaV) responsible for initiation and propagation of AP in isolated adult zebrafish fast skeletal muscle fibers and compared them to mouse fast-twitch muscle fibers using the same experimental conditions. We found that kinetics of activation and inactivation of NaV wer

SUBMITTER: Demesmay L 

PROVIDER: S-EPMC12604801 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature