Impact of age on aortic valve calcium progression and risk for aortic stenosis: multi-ethnic study of atherosclerosis.

ABSTRACT:

Aims

Aortic valve calcium (AVC) is strongly associated with the risk for severe aortic stenosis (AS). The prevalence of AVC increases with age, but the impact of age on the progression of AVC and its association with moderate-severe AS is unknown.

Methods and results

Our study included 6810 participants (52.9% women) without overt cardiovascular disease between ages 45 and 84 from the Multi-Ethnic Study of Atherosclerosis. AVC was measured using non-contrast cardiac CT at Visit 1. Progression was calculated as the change in AVC divided by years between CT scans (2-10 years). Incident moderate-severe AS was adjudicated using medical chart review and echocardiogram data from Visit 6 (median follow-up of 16 years). The association between AVC and moderate-severe AS was assessed

SUBMITTER: Marrero N 

PROVIDER: S-EPMC12604811 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature