Integrative single-cell and bulk transcriptomes analyses reveal T cell-related prognostic risk model and tumor immune microenvironment modulation in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is among the most common and lethal cancers worldwide. Recent advances in tumor immunotherapy have highlighted the importance of T-cell subsets and the tumor microenvironment (TME) in CRC, both critical for mounting a successful anti-tumor immune response. Thus, there is an urgent need for comprehensive research in these areas to accelerate the development of personalized immunotherapeutic strategies for CRC patients. Therefore, this study aims to explore T-cell heterogeneity, identify characteristic genes, and develop a reliable prognostic model to predict patient outcomes and immunotherapy responses.

Methods

CRC single-cell RNA sequencing (scRNA-seq) data were downloaded from the Gene Expression Omnibus (GEO) database. We identified T cel

SUBMITTER: Liu P 

PROVIDER: S-EPMC12604944 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature