Fer-1 alleviates traumatic brain injury-induced cognitive impairment by inhibiting hippocampal ferroptosis.

ABSTRACT: The hippocampus plays a pivotal role in the development of cognitive disorders induced by traumatic brain injury (TBI). Recent studies have elucidated the involvement of ferroptosis in the pathophysiological cascade of TBI. However, the specific role of ferroptosis and the therapeutic potential of ferrostatin-1 in mitigating hippocampal damage post-TBI remain unclear. In this study, we established a TBI model and conducted a series of behavioral and histomorphological experiments in mice to assess outcomes. Our assessments included evaluating ferroptosis levels using Perl's staining, assessing neuronal cell death through PI staining, examining mitochondrial shrinkage with transmission electron microscopy, and analyzing the expression levels of key proteins such as glutathione peroxidase 4

SUBMITTER: Kuai JX 

PROVIDER: S-EPMC12604957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature