Silver nitrate enhances antibacterial effect of colistin against intrinsic colistin resistant <i>Edwardsiella piscicida</i>.

ABSTRACT: Edwardsiella piscicida (E. piscicida) has been recognized as an important bacterial pathogen affecting fish, and it is also intrinsically resistant to colistin. E. piscicida infects many species of cultured fish and aquatic animals, posing a significant threat to the global aquaculture industry and ecological systems. Therefore, alternative treatment strategies are urgently required to combat E. piscicida infections effectively. In this study, the combination of silver nitrate and colistin demonstrated strong bactericidal activity against both in vitro and in vivo. Silver nitrate significantly reduced the minimum inhibitory concentration (MIC) of E. piscicida and enhanced the antibacterial effect of colistin against E. piscicida. More

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12604994 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature