Association of serum chemokine (C-C motif) 21 and receptor (C-C motif) 7 with Hashimoto's thyroiditis--a preliminary clinical investigation.

ABSTRACT:

Objective

To investigate the associations of serum chemokine C-C motif 21 (CCL21) and chemokine C-C motif receptor 7 (CCR7) levels with the Hashimoto's thyroiditis.

Methods

We recruited 244 subjects (183 with Hashimoto's thyroiditis and 61 healthy controls) from the Second People's Hospital of Huai'an City. Patients with Hashimoto's thyroiditis were divided into three groups according to the type of thyroid autoantibody: a. Double-positive group [elevated both thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb)]; b. TgAb group (elevated TgAb only); c. TPOAb group (elevated TPOAb only), they were further stratified according to thyroid function. We analyzed the between-group differences in the serum CCL21 and CCR7 levels which were quantified by enzyme-linke

SUBMITTER: Gui X 

PROVIDER: S-EPMC12604999 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature