Integrative multi-omic profiling in blood reveals distinct immune and metabolic signatures between ACPA-negative and ACPA-positive rheumatoid arthritis.

ABSTRACT:

Objective

To investigate whether patients with ACPA-negative (ACPA-) and ACPA-positive (ACPA+) rheumatoid arthritis (RA) exhibit distinct immune and metabolic profiles in blood, using integrative proteomic and metabolomic analyses. By uncovering subgroup-specific molecular signatures, we aim to improve the biological understanding of RA heterogeneity and support the development of more precise diagnostic and stratification strategies.

Methods

We performed high-throughput proteomic and metabolomic profiling on plasma from a well-characterized cohort comprising 40 patients with ACPA- RA, 40 patients with ACPA+ RA, and 40 healthy controls. To identify key immune and metabolic differences, we applied statistical comparisons, pathway enrichment analyses, and network inference met

SUBMITTER: Hur B 

PROVIDER: S-EPMC12605004 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature