BATF2-mediated control of astrocyte proliferation.

ABSTRACT: Astrocyte proliferation in the central nervous system is tightly controlled and is driven by the coordinated expression of regulatory proteins, including cyclins and cyclin-dependent kinases (CDKs), that dictate cell cycle progression. While most of the postnatal proliferation in the central nervous system occurs in well-defined stem cell niches, proliferation of differentiated glial cells can also be observed to maintain local populations during homeostasis and in response to inflammation. However, the transcriptional programs that regulate homeostatic proliferation of terminally differentiated astrocytes are not fully understood. Here, we identify a novel basic leucine zipper ATF-like transcription factor 2 (BATF2) as a prominent regulator of cell cycle genes in astrocytes. Specifically,

SUBMITTER: Tinkey RA 

PROVIDER: S-EPMC12605025 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature