CD163 Expression Protects Against Early Hepatic Steatosis in Western Diet-Fed Male Mice.

ABSTRACT:

Background and aims

Sustained and excessive consumption of dietary lipids and sugars can lead to hepatic steatosis triggering metabolic dysfunction-associated steatohepatitis (MASH) characterized by inflammation and hepatocellular damage. The activation of macrophages is suggested to play an important role in the pathogenesis of MASH. Liver macrophages have a high expression of the macrophage-specific scavenger receptor CD163, but during MASH development CD163 undergoes increased shedding and downregulated expression in the liver. In this study, we investigate the relation between the expression of CD163 and early hepatic steatosis in mice.

Methods

The time-dependent relation between steatosis and CD163 expression was evaluated by staining of liver specimens from male mice a

SUBMITTER: Skytthe M 

PROVIDER: S-EPMC12605062 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature