Tricuspid vs Bicuspid Aortic Valve Endocarditis: Delayed Symptom-Onset-to-Diagnosis Time in Bicuspid Patients Increases Their Complication Burden.

ABSTRACT:

Background

Bicuspid aortic valve infective endocarditis (BAV-IE) patients exhibit more perivalvular complications as compared to tricuspid aortic valve (TAV) IE.

Objectives

We examined symptom-to-diagnosis time in BAV-IE vs TAV-IE and its effect on outcomes.

Methods

Consecutive adult patients (≥18 years) with native aortic valve IE were retrospectively reviewed from all Mayo Clinic US sites from 2015 to 2021. Clinical features, microbiology, and outcomes were extracted from electronic health records. IE-related major adverse cardiovascular events (IE-related MACE) were perivalvular infection extension, septic embolism, heart failure, and/or surgery.

Results

There were 52 BAV-IE patients (mean age 47 ± 15 years, 85% [44/52] male) and 244 with TAV-IE (mean age 65

SUBMITTER: Huntley GD 

PROVIDER: S-EPMC12605079 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature