Case Report: Delayed-type hypersensitivity reaction to meropenem in an elderly patient-successful management with imipenem-cilastatin.

ABSTRACT: Meropenem is a clinically essential carbapenem antibiotic with a broad antimicrobial spectrum, potent antibacterial efficacy, and high stability against β-lactamase, which plays a pivotal role in anti-infective therapy. In clinical practice, meropenem generally shows a favorable safety and tolerability profile, with relatively few reports of serious adverse reactions. Here, we present a case of an 80-year-old woman who developed a delayed-type hypersensitivity (DTH) reaction after receiving anti-infective treatment with meropenem. This allergic reaction was immediately managed with calcium gluconate, dexamethasone sodium phosphate, and ebastine. Meanwhile, meropenem was discontinued and replaced with imipenem-cilastatin to control the infection. Following a 14-day antimicrobial ther

SUBMITTER: He C 

PROVIDER: S-EPMC12605085 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature