CEST MRI detects antiretroviral drug toxicities in the developing mouse brain.

ABSTRACT: Advances in antiretroviral drugs (ARVs) have achieved remarkable success in preventing gestational human immunodeficiency virus type 1 (HIV-1) transmission from mother to fetus. This is reflected in the rising numbers of HIV-1-exposed uninfected (HEU) children. Worldwide, the number of HEU children exceeds sixteen million, with more than one million children joining this group each year. Although HEU children remain uninfected, they are at an increased risk of neurodevelopmental deficits. Notably, in utero exposure to HIV-1 and ARVs is a causative factor. Both are linked to adverse neurodevelopment, warranting close clinical monitoring and therapeutic intervention. We now demonstrate that chemical exchange saturation transfer (CEST) MRI can be used to successfully monitor in uter

SUBMITTER: Summerlin M 

PROVIDER: S-EPMC12605090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature