High BMI-attributable female-specific cancers: a comprehensive analysis of the global disease burden and trends from 1990 to 2021 and projections to 2040.

ABSTRACT:

Background

High body mass index (BMI) is a key modifiable risk factor for breast, ovarian, and uterine cancer. Despite the ongoing global obesity epidemic, a systematic assessment of the long-term burden trends and disparities of these cancers attributable to high BMI is lacking, particularly across regions with different sociodemographic development. This study quantifies these trends and disparities, providing an evidence base to inform equitable global cancer prevention strategies.

Methods

We extracted data on deaths and disability-adjusted life years (DALYs) for breast, ovarian, and uterine cancer attributable to high BMI from 1990 to 2021 across 204 countries from the Global Burden of Disease 2021 study. We used Joinpoint regression to analyze temporal trends in age-sta

SUBMITTER: Sun G 

PROVIDER: S-EPMC12605095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature