Development and validation of a nomogram comprising GLUT1 and clinical characteristics for predicting overall survival in intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy arising from the intrahepatic bile duct epithelium, with increasing global incidence and poor prognosis due to late diagnosis and limited therapeutic options. Current prognostic models such as tumor-node-metastasis (TNM) staging exhibit suboptimal accuracy and lack integration of molecular biomarkers. Our study aims to explore the prognostic significance of SLC2A1 (encoding GLUT1) in iCCA and develop a predictive nomogram integrating clinical features.

Methods

We analyzed SLC2A1 (encoding GLUT1) mRNA expression in various solid tumors using The Cancer Genome Atlas (TCGA) data. Immunohistochemistry (IHC) was performed to assess GLUT1 protein expression in 95 postoperative iCCA pa

SUBMITTER: Gong LP 

PROVIDER: S-EPMC12605105 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature