The NMR-measured omega-6/omega-3 fatty acid ratio improves cardiovascular risk prediction.

ABSTRACT:

Background

Improving 10-year cardiovascular risk prediction beyond the established SCORE2 algorithm is a clinical need. The plasma omega-6/omega-3 (O6:O3) polyunsaturated fatty acid (PUFA) ratio, a marker of inflammatory balance, is a promising biomarker for enhancing risk stratification. We aimed to evaluate if adding the O6:O3 ratio to the SCORE2 model improves the prediction of major adverse cardiovascular events (MACE).

Methods

We conducted a prospective cohort study of 183,230 UK Biobank participants (aged 50-69 years, free of baseline cardiovascular disease or diabetes). The plasma O6:O3 ratio was measured by nuclear magnetic resonance (NMR) spectroscopy. We compared the predictive performance of the SCORE2 model with and without the O6:O3 ratio in an independent valid

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12605120 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature