Clinical significance of CD155 expression and correlation with immune cell infiltration in triple-negative breast cancer.

ABSTRACT:

Background

As a newly focused immune checkpoint protein in cancers, CD155 is a potential target in immunotherapy. Tumor microenvironment (TME) as a crucial regulatory factor in immunotherapy, also plays a significant role in the development and progression of triple-negative breast cancer (TNBC). This study aims to further clarify the relationship between the expression of CD155 and TME in TNBC.

Methods

We conducted a retrospective analysis of 182 patients with TNBC who underwent surgical treatment at The First Affiliated Hospital of Bengbu Medical University between January 2014 and December 2018. CD155, stromal tumor-infiltrating lymphocytes (sTILs), CD4, CD8, and CD163 expression levels in TNBC specimens were assessed by immunohistochemistry. We analyzed the expression of

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12605149 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature