Comparative microbiome profiling reveals unique signatures in multiple primary lung cancers.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality worldwide, with a rising incidence of multiple primary lung cancer (MPLC). However, the mechanisms underlying MPLC, including its early clinical diagnosis, pathogenesis and clinical management, remain poorly understood. The intratumoral microbiome is recognized to modulate the immune landscape within the tumor microenvironment (TME), potentially enhancing or suppressing antitumor immunity, thereby influencing tumor progression and therapeutic efficacy. The role of the intratumoral microbiome in MPLC development is an emerging area of research, yet its specific relationship with MPLC remains largely unexplored. This study aims to profile microbial communities in lung cancer tissues and elucidate differences betw

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12605167 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature