A novel prognostic tool for triple-negative breast cancer: creating and testing a parthanatos-related gene model.

ABSTRACT:

Background

Parthanatos is a poly (ADP-ribose) polymerase 1 (PARP1)-dependent programmed cell death pathway. However, the association between parthanatos and triple-negative breast cancer (TNBC) as well as its impact on patient prognosis remains unclear. This study aims to investigate the prognostic value of parthanatos in TNBC and to develop a predictive model for identifying potential prognostic biomarkers.

Methods

Gene expression profiles of TNBC cases were acquired from the publicly available dataset of The Cancer Genome Atlas (TCGA). After reviewing existing literature on parthanatos, we pinpointed 31 genes related with this process, hereafter termed parthanatos-related genes (PRGs). Using correlation analysis, we identified 1,569 messenger RNAs (mRNAs) showing strong as

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12605213 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature