Esophageal cancer mortality trends in the United States: a comprehensive longitudinal study (1999-2023) using CDC WONDER data.

ABSTRACT:

Background

Esophageal cancer continues to pose a significant public health challenge worldwide. However, the extent to which advancements in treatment have reduced mortality at the population level remains unclear. This study examines trends in esophageal cancer mortality in the United States from 1999 to 2023, focusing on variations based on sex, ethnicity, urbanization level, census region, and age group.

Methods

Mortality data were obtained from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database using ICD-10 codes (C15.0-C15.9) to identify esophageal cancer-related deaths. The analysis included individuals aged 25 years and older. Temporal trends in age-adjusted mortality rates (AAMR) were analyzed us

SUBMITTER: Yang X 

PROVIDER: S-EPMC12605218 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature