Distinct phenotypic signatures between anejaculation and premature ejaculation: evidence from a large clinical cohort.

ABSTRACT:

Background

Anejaculation (AE) and premature ejaculation (PE) are clinically distinct but mechanistically complex disorders. While both contribute substantially to male sexual health burden, their comparative profiles have not been systematically delineated in large cohorts.

Methods

We retrospectively analyzed 542 men (AE = 249, PE = 293) at a tertiary andrology clinic. All participants underwent vibration perception threshold (VPT) testing at ten standardized sites, spinal MRI reviewed by blinded radiologists, expressed prostatic secretion microscopy with supportive ultrasound for prostatitis, and validated psychological assessments (PHQ-9, GAD-7, SDI-2). Statistical comparisons used Mann-Whitney U tests, chi-squared tests, and multivariate analysis of variance (MANOV

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12605219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature