Identification and validation of RAS signaling-related genes for prognostic prediction and immunological characterization in gastric cancer.

ABSTRACT:

Background

Among global cancer statistics, gastric cancer (GC) holds the fifth spot for incidence and is the fourth most common contributor to cancer mortality. The RAS genes constitute the most commonly altered gene family in human malignancies, accounting for nearly 19% of cancer patients carrying RAS mutations. Therefore, this report investigated the relationship between RAS and GC, for providing a new perspective on the outcomes associated with GC.

Methods

Transcriptome profiles and matching clinical information of GC patients were retrieved from The Cancer Genome Atlas (TCGA) database. Univariate Cox analysis was combined with the least absolute shrinkage and selection operator (LASSO) regression to construct the prognostic model. The prognostic model's effectiveness wa

SUBMITTER: Cao J 

PROVIDER: S-EPMC12605221 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature