Ultrasound and immunohistochemical predictors of neoadjuvant chemotherapy response in breast cancer.

ABSTRACT:

Background

Neoadjuvant chemotherapy (NAC) has become a crucial treatment strategy for breast cancer. However, responses to NAC vary significantly among patients-while some achieve a pathological complete response (pCR), others exhibit limited efficacy. Therefore, identifying reliable preoperative predictors of NAC response is essential for optimizing personalized treatment decisions. This study aims to: (I) evaluate the predictive value of preoperative ultrasound characteristics in combination with immunohistochemical markers for NAC efficacy in breast cancer patients; (II) identify key indicators that synergistically enhance predictive accuracy; and (III) provide a comprehensive and practical foundation for clinical decision-making.

Methods

We retrospectively analyzed breas

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12605243 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature