Liriopesides B inhibits proliferation and metastasis and induces apoptosis of oral squamous cell carcinoma via the PI3K/Akt/mTOR signaling pathway.

ABSTRACT:

Background

Liriopesides B (LPB), a steroidal saponin derived from Liriope spicata, demonstrates potent anti-tumor activity across multiple malignancies. Nevertheless, its influence on oral squamous cell carcinoma (OSCC) has not been investigated. This study aims to evaluate the anti-OSCC properties of LPB and elucidate the underlying mechanisms.

Methods

Proliferation of OSCC cells treated with LPB was evaluated via Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell migration, invasion, and apoptosis were analyzed, along with measuring related gene expression utilizing quantitative reverse transcription polymerase chain reaction (qRT-PCR). Transcriptomic analysis of LPB-treated cells was performed, and protein levels within the PI3K/Akt/mTOR cascade were examined b

SUBMITTER: Wei J 

PROVIDER: S-EPMC12605251 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature