Identification and validation of key mitophagy-related biomarkers in the pathogenesis of proliferative diabetic retinopathy.

ABSTRACT:

Introduction

Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus, and proliferative diabetic retinopathy (PDR) represents its advanced stage. The etiology of PDR is complex. Mitophagy, the selective degradation of dysfunctional mitochondria, is crucial for cellular homeostasis and has been implicated in PDR pathogenesis. However, its specific mechanisms require further investigation.

Materials and methods

Gene Expression Omnibu (GEO) datasets (GSE102485, GSE60436) were analyzed in R software to identify differentially expressed mitophagy-related genes (DEMRGs). A PDR diagnostic model was constructed by gene ontology (GO) enrichment analysis, genome enrichment analysis (GSEA), and other relevant methods. Immune infiltration was

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12605334 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature