Development and validation of nomograms predicting survival in operable breast cancer patients at reproductive age after breast conserving surgery and postoperative radiotherapy based on SEER database.

ABSTRACT:

Background

Breast cancer (BC) in women of reproductive age (<45 years) is characterized by aggressive biology and elevated recurrence risk despite curative breast-conserving surgery (BCS) and radiotherapy. Current staging systems inadequately predict outcomes in this population, necessitating precision tools to guide therapy. This study aims to develop validated nomograms integrating clinicopathologic variables to improve survival prediction and therapeutic personalization for young operable BC patients.

Methods

Using the Surveillance, Epidemiology, and End Results (SEER) database (2010-2016), we analyzed 9,477 women aged 20-45 years with operable BC (T1-3N0-1M0) treated with BCS and radiotherapy. Prognostic factors for overall survival (OS) and cancer-specific survival (CSS

SUBMITTER: Zhu S 

PROVIDER: S-EPMC12605336 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature