<i>Pdgfrα</i> deficiency in islet β-cells up-regulates apoptosis of beta-cells and disturbs glucose metabolism in B6 mice.

ABSTRACT:

Introduction

Pancreatic β-cell dysfunction is a key contributor to the development of Type 2 Diabetes. The platelet-derived growth factor receptor α (PDGFRα) is known to play a crucial role in β-cell proliferation and expansion. However, its specific role in β-cell function and glucose metabolism remains unclear. This study aimed to investigate the effects of Pdgfrα deficiency on islet β-cell function and overall glucose metabolism.

Methods

To explore this, we generated β-cell-specific Pdgfrα-deficient C57BL/6 mice (Pdgfra^fl/fl Pdx1-cre⁺) and assessed their metabolic function under both normal and high-fat diet conditions. Various parameters were measured, including body weight, body fat composition, glucose metabolism, insulin content, and β-cell apopt

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12605365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature