Intratumoral disulfidptosis heterogeneity in triple-negative breast cancer, a multiomics integration analysis.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is characterized by heterogeneity and metabolic reprogramming. Disulfidptosis represents a new category of regulated cell death that is mediated by cystine and cysteine metabolism. However, the underlying mechanism related to the heterogeneity of TNBC disulfidptosis remains unclear. In this study, we aimed to analyze whether disulfidptosis exhibits heterogeneity in TNBC.

Methods

Initial molecular subtyping was performed via K-means clustering. Subsequent subtype characterization included enrichment analysis, differential activity score (DA score) analysis, and in vitro drug sensitivity assays targeting disulfidptosis pathways. The prognostic model was derived through univariate Cox regression followed by least absolute s

SUBMITTER: Dong ZX 

PROVIDER: S-EPMC12605368 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature