Neurofilament Light Chain from Neuronally Derived Extracellular Vesicles in Differentiating Parkinson's Disease from Essential Tremor with Resting Tremor.

ABSTRACT: Parkinson's disease (PD) and essential tremor with resting tremor (rET) show a remarkable symptom overlap that complicates the clinical differentiation and highlights the need for easily assessable diagnostic biomarkers. Neuronally derived extracellular vesicles (NDEVs) have been suggested as a peripheral substrate providing insights on the central nervous system pathology. Here, we assessed the accuracy of NDEV neurofilament light chain (Nf-L) levels in discriminating between PD and rET patients. Thirty-three PD and 13 rET patients and 30 healthy controls (HC) were consecutively enrolled in the study. NDEVs were obtained from serum through size exclusion chromatography followed by immunocapture based on L1CAM expression. NDEV Nf-L levels were quantified by ELISA on Ella Platform. Receiver

SUBMITTER: Mimmi S 

PROVIDER: S-EPMC12605399 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature