NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with limited therapeutic options available for advanced stages. Elucidating the molecular drivers of hepatocarcinogenesis holds promise for the development of targeted therapeutic strategies. Nuclear receptor-binding SET domain-containing protein 2 (NSD2), a histone lysine methyltransferase, is now recognized as a critical modulator of tumor progression. The aim of this study was to investigate the role of NSD2 in HCC.

Methods

Messenger ribonucleic acid (mRNA) and protein levels were determined in 20 HCC patients, publicly available databases and HCC cell lines. The in vitro and in vivo phenotypic alterations upon NSD2 knockdown, such as cell proliferation, a

SUBMITTER: Xiong M 

PROVIDER: S-EPMC12605404 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature