A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) was one of the most aggressive and deadly cancers, with limited treatment options and unfavorable prognosis. Tormentic acid, a pentacyclic triterpene, has shown promising anticancer properties in various cancers. However, its effects on PDAC remain unclear. The aim of this study was to assess the anticancer property of tormentic acid in PDAC cell lines and to attempt to understand its mechanism of action.

Methods

Effects of tormentic acid were tested in PDAC cell lines (PANC-1 and MIA PaCa-2) by employing several assays such as Cell Counting Kit-8 (CCK-8) assay for cell viability, comet assay for DNA damage, Annexin V/PI staining for apoptosis, flow cytometry for cell cycle analysis and wound healing assays for cell migratio

SUBMITTER: Alshahrani MM 

PROVIDER: S-EPMC12605405 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature