Identification of plasma cell infiltration-related gene signatures as a novel prognostic model for clear cell renal cell carcinoma.

ABSTRACT: This study aimed to identify key genes regulating plasma cell (PC) infiltration in kidney renal clear cell carcinoma (KIRC) and construct a novel prognostic model for predicting KIRC. Clear cell renal cell carcinoma is the most common malignant tumor type of the kidney, with an increasing incidence rate and low survival rates in advanced patients. Plasma cells (PCs), as terminally differentiated B cells, produce highly specific antibodies that effectively target and kill tumors through the antibody-dependent cellular cytotoxicity (ADCC) mechanism. Growing evidence has shown that PC infiltration is closely associated with the progression of various malignant tumors, including ccRCC. Therefore, identifying PC infiltration-related biomarkers is of great significance for the prognosis and trea

SUBMITTER: Sun X 

PROVIDER: S-EPMC12605426 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature