Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms.

ABSTRACT:

Background

Acquired renal cysts (ARC) are associated with kidney function decline, necessitating novel dietary pattern (DP) analyses in large cohorts.

Methods

This UK Biobank prospective cohort study (2006-2010) included participants with ≥2 dietary records, excluding those with severe kidney damage. The constructed comprehensive dietary pattern integration (CDPI) utilized reduced rank regression (RRR) and latent profile analysis (LPA). ARC cases (ICD-10: N28.1) were assessed via Cox regression for risk and dose-response, with NMR metabolites examined as mediators.

Results

Among 119,709 participants (median follow-up: 10.57 years), 850 ARC cases were identified. Lipid-rich and hyperglycemic diets increased ARC risk [e.g., HRs for G1.DP1: 1.080 (1.024, 1.139); G1.DP2:

SUBMITTER: Xu C 

PROVIDER: S-EPMC12605427 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature