Haemophagocytic lymphohistiocytosis in critically ill adults: a single-centre retrospective ICU cohort study.

ABSTRACT:

Background

Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterised by uncontrolled immune activation and multi-organ dysfunction. Whilst initially described in paediatric populations, HLH is increasingly recognised in critically ill adults, often triggered by malignancies, infections, or autoimmune diseases.

Methods

This single-centre retrospective study analysed 43 adult patients with HLH admitted to the ICU between 2008 and 2024. Clinical characteristics, laboratory parameters, organ support requirements, and outcomes were assessed. Temporal trends in routine parameters surrounding HLH diagnosis were also evaluated.

Results

The median age was 45 years (IQR: 33-60), and 65% were male. Respiratory failure (62.8%) and se

SUBMITTER: Haar M 

PROVIDER: S-EPMC12605457 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature