Anti-ovarian cancer effects of forsythiaside A: insights from <i>in vitro</i> and <i>in vivo</i> studies.

ABSTRACT:

Background

Ovarian cancer is a significant challenge due to its late-stage diagnosis and high mortality rates. The identification of new therapeutic agents is crucial. Forsythiaside A (FSA), derived from Forsythia suspensa, has demonstrated anti-cancer effects in other cancers, but its impact on ovarian cancer remains unexplored. This study was therefore undertaken to explore the potential anti-ovarian cancer activities of FSA and elucidate its underlying mechanisms in both in vitro and in vivo settings.

Methods

SK-OV-3 and OVCAR3 ovarian cancer cell lines were used for in vitro experiments. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay, cell cycle distribution was analyzed by flow cytometry, and cell migration and invasi

SUBMITTER: Guan H 

PROVIDER: S-EPMC12605461 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature