Spontaneous regression of tumors post-chemotherapy in a patient with relapsed small cell lung cancer: a case report.

ABSTRACT:

Background

Spontaneous regression (SR) of small cell lung cancer (SCLC) is an extremely rare phenomenon, and its underlying mechanisms remain unclear. Previous reports have suggested that immune-related factors, including paraneoplastic neurological syndrome (PNS) and anti-Hu antibodies, may be involved. In this report, we present a case of SCLC that demonstrated SR after initial progression, and explore the potential immunological mechanisms, particularly focusing on changes in the tumor microenvironment.

Case description

A 78-year-old Japanese male with a significant smoking history presented with two pulmonary nodules. Surgical resection revealed non-small cell lung cancer (NSCLC) and SCLC (stage IA2). Seven months later, SCLC recurrence was confirmed via transbronchial n

SUBMITTER: Miyaki T 

PROVIDER: S-EPMC12605473 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature