Immune-related long noncoding RNAs in predicting the prognosis and immune landscape of intrahepatic cholangiocarcinoma: a bioinformatics analysis with experimental verification.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are extensively involved in tumor immunity. The aim of this study was to construct an immune-related lncRNA (irlncRNA) signature for predicting the prognosis and immune landscape of intrahepatic cholangiocarcinoma (ICC) and to clarify the related mechanisms.

Methods

Transcriptome and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) database. The immune-related genes (IRGs) were collected from the ImmPort database. Coexpression analysis was used to identify the key lncRNAs related with IRGs. Differentially expressed and cox regression analysis was used to screen the differentially expressed and survival-related irlncRNAs, whose expression was measured in ICC and compared with that of normal controls via quan

SUBMITTER: Huang G 

PROVIDER: S-EPMC12605507 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature