AdipoRon promotes angiogenesis in B-cell leukemia by modulating pro-angiogenic factors through AdipoR1.

ABSTRACT:

Background

Adiponectin, a cytokine predominantly secreted by adipose tissue, is increasingly recognized for its role in cancer, including hematologic malignancies. However, its involvement in leukemia-related angiogenesis remains poorly understood. Here, we investigated the effects of AdipoRon, an adiponectin agonist, on angiogenesis in the JVM-2 lymphoblastic cell line, a model for B-cell leukemia.

Methods

The effects of AdipoRon were assessed on human umbilical vein endothelial cells (HUVECs) and JVM-2 cells using the tube formation assay. The expression of VEGF receptors, VEGF-A, HIF-1α, and CXCL-1 were investigated at both mRNA by quantitative real-time PCR and protein levels by ELISA and Western Blotting. The role of AdipoR1 and AdipoR2 in mediating AdipoRon effects was

SUBMITTER: Mallardo M 

PROVIDER: S-EPMC12605524 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature