Predictive factors for clinical outcome of palliative ventriculoperitoneal shunt in the treatment of leptomeningeal metastasis.

ABSTRACT:

Background

Leptomeningeal metastasis (LM) is associated with poor prognosis and affects the quality of life (QOL) of end-stage cancer patients, particularly when accompanied by hydrocephalus. Ventriculoperitoneal shunt (VPS) is recognized as an effective therapy for patients with this condition, but previous studies have focused on clinical effects. This study aimed to explore the predictors of clinical outcome in patients with LM who underwent VPS.

Methods

Thirty-seven patients who underwent VPS after being diagnosed with LM at Huashan Hospital, Fudan University, from June 2018 to June 2024 were enrolled. Clinical outcomes were evaluated using the Karnofsky performance status (KPS) at baseline and one week postoperatively. A good outcome was defined as a ≥30% improvement in

SUBMITTER: Min L 

PROVIDER: S-EPMC12605548 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature