Deciphering immune landscapes: an ICD-lncRNA-derived prognostic signature for pancreatic adenocarcinoma.

ABSTRACT:

Background

In recent years, immunogenic cell death (ICD) and long non-coding RNAs (lncRNAs) have been implicated in tumor invasion and growth. However, the role of ICD-associated lncRNAs in pancreatic adenocarcinoma (PAAD) remains unclear. Therefore, this study aimed to develop and validate a prognostic signature based on ICD-associated lncRNAs for PAAD patients and to explore its potential associations with immune processes.

Methods

We identified ICD-associated genes from the GeneCards database and obtained transcriptomic data and sample information for PAAD from The Cancer Genome Atlas (TCGA). Using these datasets, we primarily aimed to develop and validate a prognostic signature based on ICD-associated lncRNAs. A prognostic signature and nomogram were constructed to predi

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12605556 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature